Clinimix E (Baxter, 1656 mg / 920 mg / 824 mg / 384 mg /..., 1656 mg / 920 mg / 824 mg / 384 mg /...): Uses, Side Effects and Dosage

What is CLINIMIX E used for?

CLINIMIX E is used to provide nutrition to patients who are not receiving enough nutrition by eating food. CLINIMIX E will only be given to you under medical supervision.

How does CLINIMIX E work?

CLINIMIX E provides you with carbohydrates (sugars), amino acids (building blocks of protein) and other nutrients. This helps treat or prevent malnutrition.

What are the ingredients in CLINIMIX E?

Medicinal ingredients:

CLINIMIX E products are solutions for infusion, each supplied in a bag with two chambers:

• one chamber contains a dextrose solution with calcium chloride dihydrate
• one chamber contains a solution of amino acids plus electrolytes:

Amino acid chamber in CLINIMIX E (Blend D) contains: L-alanine, L-arginine, Glycine, L-histidine, L-isoleucine, L-leucine, L-lysine hydrochloride, L-methionine, L-phenylalanine, L-proline, L-threonine, L-tryptophan, L-tyrosine, L-valine, L serine plus electrolytes in the form of sodium chloride, dibasic potassium phosphate, and magnesium chloride hexahydrate.

Non-medicinal ingredients:

Glacial acetic acid (for pH adjustment) Hydrochloride acid (for pH adjustment) Nitrogen Water for injection

CLINIMIX E comes in the following dosage forms:

CLINIMIX E

8% Amino Acids (Blend D) with Electrolytes in 10% Dextrose with Calcium Injection

8% Amino Acids (Blend D) with Electrolytes in 14% Dextrose with Calcium Injection

Do not use CLINIMIX E if:

• You are allergic to any ingredients in CLINIMIX E or components of the container (See “What are the ingredients in CLINIMIX E?”, above).
• Your body has problems processing certain amino acids and these amino acids are included in CLINIMIX E.
• You are being administered ceftriaxone.
• You have high plasma concentrations of one of the electrolytes included in CLINIMIX E.
• You have liver failure or coma resulting from liver failure.
• You have kidney failure and are not on dialysis.
• You have hyperglycemia (too much sugar in your blood), which is not controlled.
• You have an allergy to corn or corn products since this product contains dextrose from corn.
• You have a disorder resulting in high blood levels of substances such as potassium (hyperkalemia), calcium (hypercalcemia), phosphorus (hyperphosphatemia), sodium (hypernatremia) and magnesium (hypermagnesemia).
• You are receiving calcium-containing intravenous solutions.

To help avoid side effects and ensure proper use, talk to your healthcare professional before you take CLINIMIX E. Talk about any health conditions or problems you may have, including if you:

• suffer from metabolic acidosis (when the blood is excessively acid)
• have kidney problems
• have liver problems

• are pregnant or intend to become pregnant

• are breastfeeding or intend to breastfeed
• have pulmonary edema (collection of fluid into the lung tissue)
• have heart problems or have had heart problems
• have fluid overload (too much water in your body), where you have experienced high blood pressure, gaining weight in short period of time, swelling in the ankles and legs, and shortness of breath
• have diabetes
• have hereditary fructose intolerance. This is a condition where your body cannot break down fructose properly. This product may contain small amounts of fructose.

Other warnings you should know about:

Pediatric Patients:

In newborns and infants, your healthcare professional will measure blood ammonia frequently to check for the presence of a congenital abnormality of amino acid metabolism.

Laboratory Testing:

Your doctor will need to monitor how you are doing while you are on this medicine. This means that you will need to have laboratory tests done on a routine basis.

Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.

The following may interact with CLINIMIX E:

• corticosteroids
• corticotropin
• diuretics such as amiloride, spironolactone, triamterene
• blood pressure drugs
• drugs that suppress your immune system such as tacrolimus or cyclosporine

How to take CLINIMIX E:

Usual dose:

Your doctor will give you CLINIMIX based on factors such as age, weight, condition, and any tests results that they have done. They will ensure that you are getting sufficient calories so that the amino acids will be absorbed. Always be sure to check with your doctor if anything about your condition changes.

Overdose:

If your dose is too high or is infused too quickly, the following may happen:

• the amino acid content may make your blood too acidic;
• the dextrose content may increase the glucose in your blood and urine;

Giving too high a volume may cause fluid overload.

To help prevent these events, your doctor will routinely check your condition, and test your blood and urine.

Missed Dose:

If you feel a dose has been missed contact your healthcare provider.

What are possible side effects from using CLINIMIX E?

These are not all the possible side effects you may have when taking CLINIMIX E. If you experience any side effects not listed here, tell your healthcare professional.

If you notice any changes in the way you feel during or after the treatment, tell your healthcare professional or another member of your medical team immediately.

The tests your healthcare professional will perform while you are taking the medication should reduce the risk of side effects.

Side effects may include:

• headache
• sweating
• reddening and stinging at the point where the tubing enters the body

Serious side effects and what to do about them

If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, tell your healthcare professional.

Reporting Side Effects

Storage:

Store at temperatures between 15°C and 25°C protected from light and kept from freezing. The prepared amino acids/dextrose admixture should be administered immediately. If not, it should be stored under refrigeration (2° - 8°C) and used within 24 hours.

Mix thoroughly when additives have been introduced. Do not store solutions containing additives.

Keep out of reach and sight of children.

If you want more information about CLINIMIX E:

• Talk to your healthcare professional
• Find the full product monograph that is prepared for healthcare professionals and includes this Patient Medication Information by visiting the Health Canada website: (https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/drug-product-database.html; the manufacturer’s website (Baxter.ca), or by calling 1-888-719-9955.

Baxter, Clinimix, Clarity and Travasol are registered trademarks of Baxter International Inc.

Last Revised MAR 31, 2022