Patient Medication Information: uses, side effects, how to take - Heparin Sod and 0.9% Sod Chloride Inj
What is Heparin Sodium in 0.9% Sodium Chloride Injection used for?
This medication belongs to a group of medicines known as anticoagulants. Heparin Sodium in 0.9% Sodium Chloride Injection is used as anticoagulant in extracorporeal circulation and dialysis procedure. It is also used as an aid in maintenance of catheter patency.
How does Heparin Sodium in 0.9% Sodium Chloride Injection work?
This medication works by decreasing the clotting ability of your blood and helps to stop clots from forming in the blood vessels.
What are the ingredients in Heparin Sodium in 0.9% Sodium Chloride Injection?
Medicinal ingredients: Heparin Sodium, USP
Sodium Chloride, USP
Non-medicinal ingredients: Citric Acid, Anhydrous, USP
Dibasic Sodium Phosphate, USP
For a full listing of nonmedicinal ingredients see Part 1 of the product monograph.
Heparin Sodium in 0.9% Sodium Chloride Injection comes in the following dosage forms:
- Intravenous solution of 1000 USP Heparin Units in 500mL 0.9% Sodium Chloride Injection
- Intravenous solution of 2000 USP Heparin Units in 1000mL 0.9% Sodium Chloride Injection
Do not use Heparin Sodium in 0.9% Sodium Chloride Injection if:
Do not use this medication if you have had or currently have any of the following:
- A known allergy to heparin, pork, or sulfites.
- a severe decrease in the number of platelets in the blood
- uncontrollable bleeding
To help avoid side effects and ensure proper use, talk to your healthcare professional before you take Heparin Sodium in 0.9% Sodium Chloride Injection. Talk about any health conditions or problems you may have, including if you:
- you are having an epidural or spinal anaesthetic. It is important that you remind your doctor that you are receiving heparin infusion before you receive any anaesthetic
- you have or have had in the past, injury or surgery on the brain, spinal cord, or eyes
- you have any condition which makes you likely to bleed more easily, regardless of the reason. Ask your doctor if unsure.
- you are menstruating.
you often consume alcohol.
- you suffer from kidney or liver problems.
you are pregnant or nursing or may become pregnant.
- you are over 60 years of age.
- you have a severe decrease in the number of platelets in the blood
- you have bacterial infection inside of the heart (bacterial endocarditis)
- you have high blood pressure (hypertension)
- you have ulcerative lesions of the small intestine or stomach
Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.
The following may interact with Heparin Sodium in 0.9% Sodium Chloride Injection
- Drugs that affect blood clotting (e.g. anticoagulants, antithrombotic drugs, platelet inhibitors, and thrombolytics). You may be likely to bleed more easily.
- Non-steroidal anti-inflammatory drugs (e.g. ibuprofen) for arthritis or pain. You may be likely to bleed more easily
- Salicylates (such as aspirin) for reducing pain and inflammation, or for stopping harmful blood clots from forming. You may be likely to bleed more easily
- Digitalis, tetracyclines, nicotine, and antihistamines. These medications may partially counteract the anticoagulant activity of heparin sodium
How to take Heparin Sodium in 0.9% Sodium Chloride Injection
Usual dose:
Your doctor will determine your dosage according to the results of suitable laboratory tests.
The rate for infusion of the medication is dependent upon age, weight, clinical condition of the patient and the procedure being employed.
Administration:
Heparin is not intended for intramuscular use.
Your doctor should not use Heparin Sodium in 0.9% Sodium Chloride Injection for catheter lock flush procedure.
Overdose:
Bleeding is the primary sign of heparin sodium overdosage. Nosebleeds, blood in urine, tarry stools or easy bruising may be noted as the first sign of bleeding.
| If you think you, or a person you are caring for, have taken too much Heparin Sodium in 0.9% Sodium Chloride Injection contact a healthcare professional, hospital emergency department, or regional poison control centre immediately, even if there are no symptoms. |
What are possible side effects from using Heparin Sodium in 0.9% Sodium Chloride
Injection?
This medication may cause side effects. These are not all the possible side effects you may have when taking Heparin Sodium in 0.9% Sodium Chloride Injection. If you experience any side effects not listed here, tell your healthcare professional. Ask your doctor or nurse to answer any questions that you may have.
Serious side effects and what to do about them
| Symptom / effect | Talk to your healthcare professional | Stop taking drug and get immediate medical help | |
|---|---|---|---|
| Only if severe | In all cases | ||
| Frequency not known | |||
| Tingling, weakness or numbness in legs or lower body, back pain, loss of control of bowel or bladder after epidural or spinal anaesthesia | √ | ||
| Signs of stroke (bleeding in the brain) such as severe headache, severe nausea and vomiting, dizziness, confusion | √ | ||
| Signs of bleeding in the abdomen: abdominal or stomach pain, back pain, blood in urine or stool, vomiting of blood, black stool (tarry stool) | √ | ||
| Signs of allergic reaction to medication: rash, itching, hives on the skin, swelling of the face, | √ | ||
Serious side effects and what to do about them
| Symptom / effect | Talk to your healthcare professional | Stop taking drug and get immediate medical help |
|---|
| Only if severe | In all cases | ||
|---|---|---|---|
| lips, tongue or other parts of the body, shortness of breath, wheezing, trouble breathing | |||
| Chest pain, rapid or unusual heartbeat | √ | ||
| Bleeding episodes, unexplained nosebleeds, heavy menstrual periods, bleeding from gums while brushing teeth, bleeding or oozing from surgical wounds | √ | ||
| Spontaneous bruising (bruise not caused by injury) | √ | ||
| Unexplained skin lesions (sores) | √ | ||
| Pain or swelling of legs or feet | √ | ||
| Discoloration (purple or red) and pain around the injection site | √ | ||
| Prolonged, painful erection | √ | ||
| Fever | √ | ||
| Chills | √ | ||
The above events were reported in the post-marketing setting.
If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, tell your healthcare professional.
Reporting Side Effects
You can report any suspected side effects associated with the use of health products to Health Canada by:
NOTE: Contact your health professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice. |
Storage:
Store at room temperature (15 to 25°C). Protect from freezing. Excessive heat should be avoided.
Keep out of reach and sight of children.
If you want more information about Heparin Sodium in 0.9% Sodium Chloride Injection
- Talk to your healthcare professional
- Find the full product monograph that is prepared for healthcare professionals and includes this Patient Medication Information by visiting the Health Canada website: (https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/drug-product-database.html; the manufacturer’s website https://www.baxter.ca or by contacting the sponsor, Baxter Corporation, at: 1-800-387-8399. .
Mississauga, ON L5N 0C2.